PND33 IMPROVED QUALITY OF LIFE AMONG RELAPSINGREMITTING MULTIPLE SCLEROSIS PATIENTS TREATED LONG-TERM WITH GLATIRAMER ACETATE
نویسندگان
چکیده
منابع مشابه
Therapy with glatiramer acetate for multiple sclerosis.
BACKGROUND Some clinical data have shown that glatiramer acetate (Copaxone), a synthetic amino acid polymer empirically found to suppress experimental allergic encephalomyelitis (EAE), an animal model of MS, might help improve the outcome of patients with multiple sclerosis (MS). OBJECTIVES We performed a Cochrane review of all randomised, placebo-controlled trials of glatiramer acetate in MS...
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Objective: Multiple sclerosis (MS) has several physical, psychological, and psychiatric symptoms. Regarding the psychological impact of MS on aspects of life, this study sought to examine the effect of group quality of life therapy on depression and anxiety in these patients. Methods: Two groups of 15 matched patients with MS were randomly assigned to experimental and control groups after co...
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BACKGROUND The balance between T helper cells Th2- and Th1-related cytokines plays a key role in multiple sclerosis (MS). A shift from a Th1 towards a Th2 cytokine profile could have a beneficial effect on the clinical course of the disease. The objective of this study was to assess Th2/Th1 cytokine profile in relapsing-remitting MS (RRMS) patients receiving an immunosuppressive treatment with ...
متن کاملMetabolic response to glatiramer acetate therapy in multiple sclerosis patients
Glatiramer acetate (GA; Copaxone) is a random copolymer of glutamic acid, lysine, alanine, and tyrosine used for the treatment of patients with multiple sclerosis (MS). Its mechanism of action has not been already fully elucidated, but it seems that GA has an immune-modulatory effect and neuro-protective properties. Lymphocyte mitochondrial dysfunction underlines the onset of several autoimmune...
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Methods The 38-year-old woman with a diagnosis of MS was examined from April until July 2013 at the Allergology Unit, Department of Internal Medicine and Gastroenterology. In the absence of specific IgE tests against GA, a basophil activation test (BAT) was performed with a borderline result (GA concentration 1.0 ul/ml with 7.8% activated basophils, stimulation index 2.1). Then followed the GA ...
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ژورنال
عنوان ژورنال: Value in Health
سال: 2008
ISSN: 1098-3015
DOI: 10.1016/s1098-3015(10)70466-6